Ontology highlight
ABSTRACT:
SUBMITTER: Liang L
PROVIDER: S-EPMC4416961 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Liang Liming L Willis-Owen Saffron A G SAG Laprise Catherine C Wong Kenny C C KCC Davies Gwyneth A GA Hudson Thomas J TJ Binia Aristea A Hopkin Julian M JM Yang Ivana V IV Grundberg Elin E Busche Stephan S Hudson Marie M Rönnblom Lars L Pastinen Tomi M TM Schwartz David A DA Lathrop G Mark GM Moffatt Miriam F MF Cookson William O C M WOCM
Nature 20150218 7549
Immunoglobulin E (IgE) is a central mediator of allergic (atopic) inflammation. Therapies directed against IgE can alleviate hay fever and allergic asthma. Genetic association studies have not yet identified novel therapeutic targets or pathways underlying IgE regulation. We therefore surveyed epigenetic associations between serum IgE concentrations and methylation at loci concentrated in CpG islands genome wide in 95 nuclear pedigrees, using DNA from peripheral blood leukocytes. We validated po ...[more]