Ontology highlight
ABSTRACT:
SUBMITTER: Lam KH
PROVIDER: S-EPMC4417461 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Progress in biophysics and molecular biology 20150219 2-3
Botulinum neurotoxins (BoNTs) are among the most deadly toxins known. They act rapidly in a highly specific manner to block neurotransmitter release by cleaving the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) complex at neuromuscular junctions. The extreme toxicity of BoNTs relies predominantly on their neurotropism that is accomplished by recognition of two host receptors, a polysialo-ganglioside and in the majority of cases a synaptic vesicle protein, through ...[more]