Ontology highlight
ABSTRACT:
SUBMITTER: Schmitt J
PROVIDER: S-EPMC2894633 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Schmitt John J Karalewitz Andrew A Benefield Desirée A DA Mushrush Darren J DJ Pruitt Rory N RN Spiller Benjamin W BW Barbieri Joseph T JT Lacy D Borden DB
Biochemistry 20100601 25
Botulinum neurotoxin (BoNT) binds peripheral neurons at the neuromuscular junction through a dual-receptor mechanism that includes interactions with ganglioside and protein receptors. The receptor identities vary depending on BoNT serotype (A-G). BoNT/B and BoNT/G bind the luminal domains of synaptotagmin I and II, homologous synaptic vesicle proteins. We observe conditions under which BoNT/B binds both Syt isoforms, but BoNT/G binds only SytI. Both serotypes bind ganglioside G(T1b). The BoNT/G ...[more]