Ontology highlight
ABSTRACT:
SUBMITTER: Berntsson RP
PROVIDER: S-EPMC3752466 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Berntsson Ronnie P-A RP Peng Lisheng L Dong Min M Stenmark Pål P
Nature communications 20130101
Botulinum neurotoxins are highly toxic, and bind two receptors to achieve their high affinity and specificity for neurons. Here we present the first structure of a botulinum neurotoxin bound to both its receptors. We determine the 2.3-Å structure of a ternary complex of botulinum neurotoxin type B bound to both its protein receptor synaptotagmin II and its ganglioside receptor GD1a. We show that there is no direct contact between the two receptors, and that the binding affinity towards synaptota ...[more]