Ontology highlight
ABSTRACT:
SUBMITTER: Yang SH
PROVIDER: S-EPMC3521700 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Yang Shen-Hsi SH Kalkan Tuzer T Morrisroe Claire C Smith Austin A Sharrocks Andrew D AD
PLoS genetics 20121213 12
Embryonic stem cells and induced pluripotent stem cells represent potentially important therapeutic agents in regenerative medicine. Complex interlinked transcriptional and signaling networks control the fate of these cells towards maintenance of pluripotency or differentiation. In this study we have focused on how mouse embryonic stem cells begin to differentiate and lose pluripotency and, in particular, the role that the ERK MAP kinase and GSK3 signaling pathways play in this process. Through ...[more]