Ontology highlight
ABSTRACT:
SUBMITTER: Gupta K
PROVIDER: S-EPMC4423116 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
eLife 20150507
Tarantula toxins that bind to voltage-sensing domains of voltage-activated ion channels are thought to partition into the membrane and bind to the channel within the bilayer. While no structures of a voltage-sensor toxin bound to a channel have been solved, a structural homolog, psalmotoxin (PcTx1), was recently crystalized in complex with the extracellular domain of an acid sensing ion channel (ASIC). In the present study we use spectroscopic, biophysical and computational approaches to compare ...[more]