Ontology highlight
ABSTRACT:
SUBMITTER: Halavaty AS
PROVIDER: S-EPMC4427200 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Halavaty Andrei S AS Rich Rebecca L RL Chen Chao C Joo Jeong Chan JC Minasov George G Dubrovska Ievgeniia I Winsor James R JR Myszka David G DG Duban Mark M Shuvalova Ludmilla L Yakunin Alexander F AF Anderson Wayne F WF
Acta crystallographica. Section D, Biological crystallography 20150425 Pt 5
When exposed to high osmolarity, methicillin-resistant Staphylococcus aureus (MRSA) restores its growth and establishes a new steady state by accumulating the osmoprotectant metabolite betaine. Effective osmoregulation has also been implicated in the acquirement of a profound antibiotic resistance by MRSA. Betaine can be obtained from the bacterial habitat or produced intracellularly from choline via the toxic betaine aldehyde (BA) employing the choline dehydrogenase and betaine aldehyde dehydro ...[more]