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Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.

ABSTRACT: Burkholderia pseudomallei infection causes melioidosis, which is often fatal if untreated. There is a need to develop new and more effective treatments for melioidosis. This study reports apo and cofactor-bound crystal structures of the potential drug target betaine aldehyde dehydrogenase (BADH) from B. pseudomallei. A structural comparison identified similarities to BADH from Pseudomonas aeruginosa which is inhibited by the drug disulfiram. This preliminary analysis could facilitate drug-repurposing studies for B. pseudomallei.

SUBMITTER: Beard DK

PROVIDER: S-EPMC8805214 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.

Beard Dylan K DK Subramanian Sandhya S Abendroth Jan J Dranow David M DM Edwards Thomas E TE Myler Peter J PJ Asojo Oluwatoyin A OA

Acta crystallographica. Section F, Structural biology communications 20220127 Pt 2

Burkholderia pseudomallei infection causes melioidosis, which is often fatal if untreated. There is a need to develop new and more effective treatments for melioidosis. This study reports apo and cofactor-bound crystal structures of the potential drug target betaine aldehyde dehydrogenase (BADH) from B. pseudomallei. A structural comparison identified similarities to BADH from Pseudomonas aeruginosa which is inhibited by the drug disulfiram. This preliminary analysis could facilitate drug-repurp ...[more]

PMID: 35102892

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