Ontology highlight
ABSTRACT:
SUBMITTER: Chu HL
PROVIDER: S-EPMC4430538 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Chu Hung-Lun HL Yip Bak-Sau BS Chen Kuan-Hao KH Yu Hui-Yuan HY Chih Ya-Han YH Cheng Hsi-Tsung HT Chou Yu-Ting YT Cheng Jya-Wei JW
PloS one 20150513 5
We describe a strategy to boost anticancer activity and reduce normal cell toxicity of short antimicrobial peptides by adding positive charge amino acids and non-nature bulky amino acid β-naphthylalanine residues to their termini. Among the designed peptides, K4R2-Nal2-S1 displayed better salt resistance and less toxicity to hRBCs and human fibroblast than Nal2-S1 and K6-Nal2-S1. Fluorescence microscopic studies indicated that the FITC-labeled K4R2-Nal2-S1 preferentially binds cancer cells and c ...[more]