Ontology highlight
ABSTRACT:
SUBMITTER: Young DC
PROVIDER: S-EPMC4432472 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Young David C DC Layre Emilie E Pan Shih-Jung SJ Tapley Asa A Adamson John J Seshadri Chetan C Wu Zhongtao Z Buter Jeffrey J Minnaard Adriaan J AJ Coscolla Mireia M Gagneux Sebastien S Copin Richard R Ernst Joel D JD Bishai William R WR Snider Barry B BB Moody D Branch DB
Chemistry & biology 20150401 4
Although small molecules shed from pathogens are widely used to diagnose infection, such tests have not been widely implemented for tuberculosis. Here we show that the recently identified compound, 1-tuberculosinyladenosine (1-TbAd), accumulates to comprise >1% of all Mycobacterium tuberculosis lipid. In vitro and in vivo, two isomers of TbAd were detected that might serve as infection markers. Using mass spectrometry and nuclear magnetic resonance, we established the structure of the previously ...[more]