Ontology highlight
ABSTRACT:
SUBMITTER: Tassi I
PROVIDER: S-EPMC4432939 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Tassi Ilaria I Rikhi Nimisha N Claudio Estefania E Wang Hongshan H Tang Wanhu W Ha Hye-Lin HL Saret Sun S Kaplan Daniel H DH Siebenlist Ulrich U
European journal of immunology 20150212 4
Bcl-3 is an atypical member of the IκB family. Bcl-3 functions as a cofactor of p50/NF-κB1 or p52/NF-κB2 homodimers in nuclei, where it modulates NF-κB-regulated transcription in a context-dependent way. Bcl-3 has tumorigenic potential, is critical in host defense of pathogens, and has been reported to ameliorate or exacerbate inflammation, depending on disease model. However, cell-specific functions of Bcl-3 remain largely unknown. Here, we explored the role of Bcl-3 in a contact hypersensitivi ...[more]