Ontology highlight
ABSTRACT:
SUBMITTER: Tassi I
PROVIDER: S-EPMC4201953 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Tassi Ilaria I Claudio Estefania E Wang Hongshan H Tang Wanhu W Ha Hye-lin HL Saret Sun S Ramaswamy Madhu M Siegel Richard R Siebenlist Ulrich U
Journal of immunology (Baltimore, Md. : 1950) 20140922 9
Bcl-3 is an atypical member of the IκB family and modulates gene expression via interaction with p50/NF-κB1 or p52/NF-κB2 homodimers. We report in the present study that Bcl-3 is required in dendritic cells (DCs) to assure effective priming of CD4 and CD8 T cells. Lack of Bcl-3 in bone marrow-derived DCs blunted their ability to expand and promote effector functions of T cells upon Ag/adjuvant challenge in vitro and after adoptive transfers in vivo. Importantly, the critical role of Bcl-3 for pr ...[more]