Dataset Information

Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets.

ABSTRACT:

Background

The present study was conducted to investigate the effects of gastric infusion of short-chain fatty acids (SCFA) on gut barrier function in a pig model. In this study, 21 DLY barrows with an average initial body weight of (8.31?±?0.72) kg were randomly allotted into three treatments: (1) control, (2) infusing low SCFA, S1, (3) infusing high SCFA, S2. The experimental period lasted for 7 days.

Results

Gastric infusion of SCFA increased the concentrations of SCFA in serum and digesta, and enhanced the mRNA and protein abundances of SCFA receptors in pig intestine (P?P?7A₁ and ileal DMT1 mRNA abundances in the SCFA infusion groups were higher than those in the control group (P?Lactobacillus spp counts in the ileal digesta, decreased the mRNA and protein abundances of IL-1? in the colon, and reduced Escherichia coli count in the ileal digesta (P?ConclusionsThese data indicated that gastric infusion of SCFA, especially high SCFA concentration, may be beneficial to gut development of piglets via improving gut morphology, decreasing apoptotic cell percentage, and maintaining intestinal barrier function.

SUBMITTER: Diao H

PROVIDER: S-EPMC6359775 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets.

Diao H H Jiao A R AR Yu B B Mao X B XB Chen D W DW

Genes & nutrition 20190201

<h4>Background</h4>The present study was conducted to investigate the effects of gastric infusion of short-chain fatty acids (SCFA) on gut barrier function in a pig model. In this study, 21 DLY barrows with an average initial body weight of (8.31 ± 0.72) kg were randomly allotted into three treatments: (1) control, (2) infusing low SCFA, S1, (3) infusing high SCFA, S2. The experimental period lasted for 7 days.<h4>Results</h4>Gastric infusion of SCFA increased the concentrations of SCFA in serum ...[more]

PMID: 30761185

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Dataset Information

Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets.

Background

Results

Publications

Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets.

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