Ontology highlight
ABSTRACT:
SUBMITTER: Niu W
PROVIDER: S-EPMC4437485 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Niu Wenze W Zang Tong T Smith Derek K DK Vue Tou Yia TY Zou Yuhua Y Bachoo Robert R Johnson Jane E JE Zhang Chun-Li CL
Stem cell reports 20150423 5
Glial cells can be in vivo reprogrammed into functional neurons in the adult CNS; however, the process by which this reprogramming occurs is unclear. Here, we show that a distinct cellular sequence is involved in SOX2-driven in situ conversion of adult astrocytes to neurons. This includes ASCL1(+) neural progenitors and DCX(+) adult neuroblasts (iANBs) as intermediates. Importantly, ASCL1 is required, but not sufficient, for the robust generation of iANBs in the adult striatum. These progenitor- ...[more]