Ontology highlight
ABSTRACT:
SUBMITTER: Polioudakis D
PROVIDER: S-EPMC4439112 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Polioudakis Damon D Abell Nathan S NS Iyer Vishwanath R VR
PloS one 20150520 5
miRNAs play a central role in numerous pathologies including multiple cancer types. miR-191 has predominantly been studied as an oncogene, but the role of miR-191 in the proliferation of primary cells is not well characterized, and the miR-191 targetome has not been experimentally profiled. Here we utilized RNA induced silencing complex immunoprecipitations as well as gene expression profiling to construct a genome wide miR-191 target profile. We show that miR-191 represses proliferation in prim ...[more]