Genetic variants in microRNA genes: impact on microRNA expression, function, and disease.
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ABSTRACT:
SUBMITTER: Cammaerts S
PROVIDER: S-EPMC4439572 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Genetic variants in microRNA genes: impact on microRNA expression, function, and disease.
Cammaerts Sophia S Strazisar Mojca M De Rijk Peter P Del Favero Jurgen J
Frontiers in genetics 20150521
MicroRNAs (miRNAs) are important regulators of gene expression and like any other gene, their coding sequences are subject to genetic variation. Variants in miRNA genes can have profound effects on miRNA functionality at all levels, including miRNA transcription, maturation, and target specificity, and as such they can also contribute to disease. The impact of variants in miRNA genes is the focus of the present review. To put these effects into context, we first discuss the requirements of miRNA ...[more]
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