Ontology highlight
ABSTRACT:
SUBMITTER: Yin F
PROVIDER: S-EPMC4440440 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yin Feng F Yang Chengbin C Wang Qianqian Q Zeng Shuwen S Hu Rui R Lin Guimiao G Tian Jinglin J Hu Siyi S Lan Rong Feng RF Yoon Ho Sup HS Lu Fei F Wang Kuan K Yong Ken-Tye KT
Theranostics 20150420 8
In this work, we report the engineering of polyelectrolyte polymers coated Gold nanorods (AuNRs)-based nanocarriers that are capable of co-delivering small interfering RNA (siRNA) and an anticancer drug doxorubicin (DOX) to Panc-1 cancer cells for combination of both chemo- and siRNA-mediated mutant K-Ras gene silencing therapy. Superior anticancer efficacy was observed through synergistic combination of promoted siRNA and DOX release upon irradiating the nanoplex formulation with 665 nm light. ...[more]