Ontology highlight
ABSTRACT:
SUBMITTER: Chowdhury M
PROVIDER: S-EPMC4440806 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20140410 4
Modular synthesis of regiospecifically fluorinated 2,4-diene Weinreb amides, with defined stereochemistry at both double bonds, was achieved via two sequential Julia-Kocienski olefinations. In the first step, a Z-a-fluorovinyl Weinreb amide unit with a benzothiazolylsulfanyl substituent at the allylic position was assembled. This was achieved via condensation of two primary building blocks, namely 2-(benzo[d]thiazol-2-ylsulfonyl)-2-fluoro-N-methoxy-N-methylacetamide (a Julia-Kocienski olefinatio ...[more]