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From ATP to PTP and Back: A Dual Function for the Mitochondrial ATP Synthase.

ABSTRACT: Mitochondria not only play a fundamental role in heart physiology but are also key effectors of dysfunction and death. This dual role assumes a new meaning after recent advances on the nature and regulation of the permeability transition pore, an inner membrane channel whose opening requires matrix Ca(2+) and is modulated by many effectors including reactive oxygen species, matrix cyclophilin D, Pi (inorganic phosphate), and matrix pH. The recent demonstration that the F-ATP synthase can reversibly undergo a Ca(2+)-dependent transition to form a channel that mediates the permeability transition opens new perspectives to the field. These findings demand a reassessment of the modifications of F-ATP synthase that take place in the heart under pathological conditions and of their potential role in determining the transition of F-ATP synthase from and energy-conserving into an energy-dissipating device.

SUBMITTER: Bernardi P

PROVIDER: S-EPMC4443805 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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From ATP to PTP and Back: A Dual Function for the Mitochondrial ATP Synthase.

Bernardi Paolo P Di Lisa Fabio F Fogolari Federico F Lippe Giovanna G

Circulation research 20150501 11

Mitochondria not only play a fundamental role in heart physiology but are also key effectors of dysfunction and death. This dual role assumes a new meaning after recent advances on the nature and regulation of the permeability transition pore, an inner membrane channel whose opening requires matrix Ca(2+) and is modulated by many effectors including reactive oxygen species, matrix cyclophilin D, Pi (inorganic phosphate), and matrix pH. The recent demonstration that the F-ATP synthase can reversi ...[more]

PMID: 25999424

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