Ontology highlight
ABSTRACT:
SUBMITTER: Taylor HE
PROVIDER: S-EPMC4447393 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Taylor Harry E HE Simmons Glenn E GE Mathews Thomas P TP Khatua Atanu K AK Popik Waldemar W Lindsley Craig W CW D'Aquila Richard T RT Brown H Alex HA
PLoS pathogens 20150528 5
Quiescent CD4+ T cells restrict human immunodeficiency virus type 1 (HIV-1) infection at early steps of virus replication. Low levels of both deoxyribonucleotide triphosphates (dNTPs) and the biosynthetic enzymes required for their de novo synthesis provide one barrier to infection. CD4+ T cell activation induces metabolic reprogramming that reverses this block and facilitates HIV-1 replication. Here, we show that phospholipase D1 (PLD1) links T cell activation signals to increased HIV-1 permiss ...[more]