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Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.

ABSTRACT: The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment.

SUBMITTER: Marchetto MC

PROVIDER: S-EPMC4447776 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises.

Marchetto Maria C MC Brennand Kristen J KJ Boyer Leah F LF Gage Fred H FH

Human molecular genetics 20110809 R2

The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine ...[more]

PMID: 21828073

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