Ontology highlight
ABSTRACT:
SUBMITTER: Healey EG
PROVIDER: S-EPMC4456160 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Healey Eleanor G EG Bishop Benjamin B Elegheert Jonathan J Bell Christian H CH Padilla-Parra Sergi S Siebold Christian C
Nature structural & molecular biology 20150504 6
Repulsive guidance molecules (RGMs) control crucial processes including cell motility, adhesion, immune-cell regulation and systemic iron metabolism. RGMs signal via the neogenin (NEO1) and the bone morphogenetic protein (BMP) pathways. Here, we report crystal structures of the N-terminal domains of all human RGM family members in complex with the BMP ligand BMP2, revealing a new protein fold and a conserved BMP-binding mode. Our structural and functional data suggest a pH-linked mechanism for R ...[more]