Dataset Information
Cryo-EM structure of the ternary Netrin 1-Neogenin 1-Repulsive Guidance Molecule B complex
Ontology highlight
ABSTRACT:
SUBMITTER: Tomas Malinauskas
PROVIDER: EMPIAR-10637 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell 20210318 8
During cell migration or differentiation, cell surface receptors are simultaneously exposed to different ligands. However, it is often unclear how these extracellular signals are integrated. Neogenin (NEO1) acts as an attractive guidance receptor when the Netrin-1 (NET1) ligand binds, but it mediates repulsion via repulsive guidance molecule (RGM) ligands. Here, we show that signal integration occurs through the formation of a ternary NEO1-NET1-RGM complex, which triggers reciprocal silencing of ...[more]