Cryo-EM structure of the ternary Netrin 1-Neogenin 1-Repulsive Guidance Molecule B complex
Ontology highlight
ABSTRACT:
SUBMITTER: Tomas Malinauskas
PROVIDER: EMPIAR-10637 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Robinson Ross A RA Griffiths Samuel C SC van de Haar Lieke L LL Malinauskas Tomas T van Battum Eljo Y EY Zelina Pavol P Schwab Rebekka A RA Karia Dimple D Malinauskaite Lina L Brignani Sara S van den Munkhof Marleen H MH Düdükcü Özge Ö De Ruiter Anna A AA Van den Heuvel Dianne M A DMA Bishop Benjamin B Elegheert Jonathan J Aricescu A Radu AR Pasterkamp R Jeroen RJ Siebold Christian C
Cell 20210318 8
During cell migration or differentiation, cell surface receptors are simultaneously exposed to different ligands. However, it is often unclear how these extracellular signals are integrated. Neogenin (NEO1) acts as an attractive guidance receptor when the Netrin-1 (NET1) ligand binds, but it mediates repulsion via repulsive guidance molecule (RGM) ligands. Here, we show that signal integration occurs through the formation of a ternary NEO1-NET1-RGM complex, which triggers reciprocal silencing of ...[more]
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