Ontology highlight
ABSTRACT:
SUBMITTER: Arnes L
PROVIDER: S-EPMC4458180 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Trends in genetics : TIG 20150323 6
Insulin-producing β cells within the pancreatic islet of Langerhans are responsible for maintaining glucose homeostasis; the loss or malfunction of β cells results in diabetes mellitus. Recent advances in cell purification strategies and sequencing technologies as well as novel molecular tools have revealed that epigenetic modifications and long noncoding RNAs (lncRNAs) represent an integral part of the transcriptional mechanisms regulating pancreas development and β cell function. Importantly, ...[more]