Ontology highlight
ABSTRACT:
SUBMITTER: Brazao TF
PROVIDER: S-EPMC5000579 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Brazão Tiago F TF Johnson Jethro S JS Müller Jennifer J Heger Andreas A Ponting Chris P CP Tybulewicz Victor L J VL
Blood 20160705 7
Long noncoding RNAs (lncRNAs) are potentially important regulators of cell differentiation and development, but little is known about their roles in B lymphocytes. Using RNA-seq and de novo transcript assembly, we identified 4516 lncRNAs expressed in 11 stages of B-cell development and activation. Most of these lncRNAs have not been previously detected, even in the closely related T-cell lineage. Comparison with lncRNAs previously described in human B cells identified 185 mouse lncRNAs that have ...[more]