Ontology highlight
ABSTRACT:
SUBMITTER: Gilman MS
PROVIDER: S-EPMC4498696 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Gilman Morgan S A MS Moin Syed M SM Mas Vicente V Chen Man M Patel Nita K NK Kramer Kari K Zhu Qing Q Kabeche Stephanie C SC Kumar Azad A Palomo Concepción C Beaumont Tim T Baxa Ulrich U Ulbrandt Nancy D ND Melero José A JA Graham Barney S BS McLellan Jason S JS
PLoS pathogens 20150710 7
Prevention efforts for respiratory syncytial virus (RSV) have been advanced due to the recent isolation and characterization of antibodies that specifically recognize the prefusion conformation of the RSV fusion (F) glycoprotein. These potently neutralizing antibodies are in clinical development for passive prophylaxis and have also aided the design of vaccine antigens that display prefusion-specific epitopes. To date, prefusion-specific antibodies have been shown to target two antigenic sites o ...[more]