Dataset Information

Ethnic differences in associations between fat deposition and incident diabetes and underlying mechanisms: the SABRE study.

ABSTRACT:

Objective

To examine ethnic differences in ectopic fat and associations with incident diabetes.

Methods

In a UK cohort study, 1338 Europeans, 838 South Asians, and 330 African Caribbeans living in London were aged 40-69 years at baseline. Baseline assessment included blood tests, anthropometry, and questionnaires. Anthropometry-based prediction equations estimated baseline visceral adipose tissue (VAT). Incident diabetes was ascertained from record review, self-report, or oral glucose tolerance testing.

Results

South Asians had more and African Caribbeans less estimated VAT than Europeans. Both ethnic minorities had larger truncal skinfolds than Europeans. In men, adjustment for risk factors (BMI, smoking, systolic blood pressure, and HDL-cholesterol) markedly attenuated the association between estimated VAT and diabetes in Europeans (standardized subhazard ratios [95% CI]: from 1.74 [1.49, 2.03] to 1.16 [0.77, 1.76]) and African Caribbeans (1.72 [1.26, 2.35] to 1.44 [0.69, 3.02]) but not South Asians (1.60 [1.38, 1.86] to 1.90 [1.37, 2.64]). In women, attenuation was observed only for South Asians (1.80 [1.01, 3.23] to 1.07 [0.49, 2.31]). Associations between truncal skinfolds and diabetes appeared less affected by multivariable adjustment in South Asians and African Caribbeans than Europeans (1.24 [0.97, 1.57] and 1.28 [0.89, 1.82] versus 1.02 [0.77, 1.36] in men; 1.91 [1.03, 3.56] and 1.42 [0.86, 2.34] versus 1.23 [0.74, 2.05] in women).

Conclusions

Differences in overall truncal fat, as well as VAT, may contribute to the excess of diabetes in South Asian and African Caribbean groups, particularly for women.

SUBMITTER: Eastwood SV

PROVIDER: S-EPMC4463764 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Publications

Ethnic differences in associations between fat deposition and incident diabetes and underlying mechanisms: the SABRE study.

Eastwood Sophie V SV Tillin Therese T Dehbi Hakim-Moulay HM Wright Andrew A Forouhi Nita G NG Godsland Ian I Whincup Peter P Sattar Naveed N Hughes Alun D AD Chaturvedi Nishi N

Obesity (Silver Spring, Md.) 20150203 3

<h4>Objective</h4>To examine ethnic differences in ectopic fat and associations with incident diabetes.<h4>Methods</h4>In a UK cohort study, 1338 Europeans, 838 South Asians, and 330 African Caribbeans living in London were aged 40-69 years at baseline. Baseline assessment included blood tests, anthropometry, and questionnaires. Anthropometry-based prediction equations estimated baseline visceral adipose tissue (VAT). Incident diabetes was ascertained from record review, self-report, or oral glu ...[more]

PMID: 25645144

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Dataset Information

Ethnic differences in associations between fat deposition and incident diabetes and underlying mechanisms: the SABRE study.

Objective

Methods

Results

Conclusions

Publications

Ethnic differences in associations between fat deposition and incident diabetes and underlying mechanisms: the SABRE study.

Similar Datasets

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