Ontology highlight
ABSTRACT:
SUBMITTER: Backes C
PROVIDER: S-EPMC4467411 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Backes Christina C Harz Christian C Fischer Ulrike U Schmitt Jana J Ludwig Nicole N Petersen Britt-Sabina BS Mueller Sabine C SC Kim Yoo-Jin YJ Wolf Nadine M NM Katus Hugo A HA Meder Benjamin B Furtwängler Rhoikos R Franke Andre A Bohle Rainer R Henn Wolfram W Graf Norbert N Keller Andreas A Meese Eckart E
Oncotarget 20150301 8
Glioblastoma multiforme (GBM) is the most aggressive and malignant subtype of human brain tumors. While a family clustering of GBM has long been acknowledged, relevant hereditary factors still remained elusive. Exome sequencing of families offers the option to discover respective genetic factors.We sequenced blood samples of one of the rare affected families: while both parents were healthy, both children were diagnosed with GBM. We report 85 homozygous non-synonymous single nucleotide variation ...[more]