Ontology highlight
ABSTRACT:
SUBMITTER: Wang LJ
PROVIDER: S-EPMC4467412 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Wang Li-Juan LJ He Chen-Chen CC Sui Xin X Cai Meng-Jiao MJ Zhou Cong-Ya CY Ma Jin-Lu JL Wu Lei L Wang Hao H Han Su-Xia SX Zhu Qing Q
Oncotarget 20150301 8
Intrahepatic cholangiocarcinoma (ICC) constitutes the second-most common primary hepatic malignancy. MicroRNAs (miRNAs) play important roles in the pathogenesis of ICC. However, the clinical significance of miR-21 levels in ICC remains unclear. Here, we investigated the role of miR-21 in ICC and found that its expression was significantly upregulated in serum of ICC patients. Serum miR-21 levels robustly distinguished ICC patients from control subjects. Further experiments showed that inhibition ...[more]