Ontology highlight
ABSTRACT:
SUBMITTER: Santer FR
PROVIDER: S-EPMC4467425 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Santer Frédéric R FR Erb Holger H H HH Oh Su Jung SJ Handle Florian F Feiersinger Gertrud E GE Luef Birgit B Bu Huajie H Schäfer Georg G Ploner Christian C Egger Martina M Rane Jayant K JK Maitland Norman J NJ Klocker Helmut H Eder Iris E IE Culig Zoran Z
Oncotarget 20150301 8
Androgen deprivation therapy induces apoptosis or cell cycle arrest in prostate cancer (PCa) cells. Here we set out to analyze whether MCL1, a known mediator of chemotherapy resistance regulates the cellular response to androgen withdrawal. Analysis of MCL1 protein and mRNA expression in PCa tissue and primary cell culture specimens of luminal and basal origin, respectively, reveals higher expression in cancerous tissue compared to benign origin. Using PCa cellular models in vitro and in vivo we ...[more]