Unknown

Dataset Information

0

Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide.

ABSTRACT: A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics.

SUBMITTER: Wu B 

PROVIDER: S-EPMC4472006 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide.

Wu Baolin B   Wei Na N   Thon Vireak V   Wei Mohui M   Yu Zaikuan Z   Xu Yongmei Y   Chen Xi X   Liu Jian J   Wang Peng George PG   Li Tiehai T  

Organic & biomolecular chemistry 20150501 18

A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics. ...[more]

Similar Datasets

Unknown Facile Chemoenzymatic Synthesis of O-Mannosyl Glycans.
| S-EPMC6097902 | biostudies-literature
Unknown Facile chemoenzymatic synthesis of a novel stable mimic of NAD.
| S-EPMC6256357 | biostudies-literature
Unknown Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids.
| S-EPMC2769491 | biostudies-other
Unknown A facile chemoenzymatic synthesis of SARS-CoV-2 glycopeptides for probing glycosylation functions.
| S-EPMC8294178 | biostudies-literature
Unknown In vitro synthesis of heparosan using recombinant Pasteurella multocida heparosan synthase PmHS2.
| S-EPMC2811250 | biostudies-literature
Unknown Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues.
| S-EPMC4076696 | biostudies-literature
Unknown Highly efficient chemoenzymatic synthesis and facile purification of ?-Gal pentasaccharyl ceramide Gal?3nLc4?Cer.
| S-EPMC5597046 | biostudies-literature
Unknown Engineer <i>P. multocida</i> Heparosan Synthase 2 (PmHS2) for Size-Controlled Synthesis of Longer Heparosan Oligosaccharides.
| S-EPMC7842274 | biostudies-literature
Unknown Synthesis of the Non-Reducing Hexasaccharide Fragment of Saccharomicin B.
| S-EPMC6465119 | biostudies-literature
Unknown Design and synthesis of unnatural heparosan and chondroitin building blocks.
| S-EPMC3092388 | biostudies-literature