Ontology highlight
ABSTRACT:
SUBMITTER: Grozeva D
PROVIDER: S-EPMC4476027 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Grozeva Detelina D Kirov George G Ivanov Dobril D Jones Ian R IR Jones Lisa L Green Elaine K EK St Clair David M DM Young Allan H AH Ferrier Nicol N Farmer Anne E AE McGuffin Peter P Holmans Peter A PA Owen Michael J MJ O'Donovan Michael C MC Craddock Nick N
Archives of general psychiatry 20100401 4
<h4>Context</h4>Recent studies suggest that copy number variation in the human genome is extensive and may play an important role in susceptibility to disease, including neuropsychiatric disorders such as schizophrenia and autism. The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date.<h4>Objectives</h4>To determine whether large (>100,000 base pairs) and rare (found in <1% of the population) CNVs are associated with susceptibility to bi ...[more]