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An expedient synthesis of maraviroc (UK-427,857) via C-H functionalization.

ABSTRACT: A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C-H functionalization.

SUBMITTER: Bedell TA

PROVIDER: S-EPMC4477708 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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An expedient synthesis of maraviroc (UK-427,857) <i>via</i> C-H functionalization.

Bedell T Aaron TA Hone Graham A B GAB Bois Justin Du JD Sorensen Erik J EJ

Tetrahedron letters 20150601 23

A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C-H functionalization. ...[more]

PMID: 26120216

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