Ontology highlight
ABSTRACT:
SUBMITTER: Dennis DG
PROVIDER: S-EPMC7305690 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20190619 26
Anthracyclines are archetypal representatives of the tetracyclic type II polyketide natural products that are widely used in cancer chemotherapy. Although the synthesis of this class of compounds has been a subject of several investigations, all known approaches are based on annulations, relying on the union of properly prefunctionalized building blocks. Herein, we describe a conceptually different approach using a polynuclear arene as a starting template, ideally requiring only functional decor ...[more]