Ontology highlight
ABSTRACT:
SUBMITTER: Jaurena MB
PROVIDER: S-EPMC4479597 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Jaurena Maria Belen MB Juraver-Geslin Hugo H Devotta Arun A Saint-Jeannet Jean-Pierre JP
Nature communications 20150623
All cranial placode progenitors arise from a common precursor field anterior to the neural plate, the pre-placodal region (PPR). We showed that transcription factor Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate. Here we reveal the non-cell autonomous activity of Zic1 and implicate retinoic acid (RA) signalling as a key player in cranial placode progenitor specification. In a screen for genes activated by Zic1, we identify several factors involv ...[more]