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Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.

ABSTRACT: Four new iodobenzene-containing dipeptides (1-4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A-E (1-5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey's analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na+/K+-ATPase (4).

SUBMITTER: Won TH

PROVIDER: S-EPMC4483659 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.

Won Tae Hyung TH Kim Chang-Kwon CK Lee So-Hyoung SH Rho Boon Jo BJ Lee Sang Kook SK Oh Dong-Chan DC Oh Ki-Bong KB Shin Jongheon J

Marine drugs 20150616 6

Four new iodobenzene-containing dipeptides (1-4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A-E (1-5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey's analysis. Several of these compounds ...[more]

PMID: 26087023

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