Ontology highlight
ABSTRACT:
SUBMITTER: Yan Y
PROVIDER: S-EPMC6358605 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Yan Yahui Y Rato Claudia C Rohland Lukas L Preissler Steffen S Ron David D
Nature communications 20190201 1
Despite its known role as a secreted neuroprotectant, much of the mesencephalic astrocyte-derived neurotrophic factor (MANF) is retained in the endoplasmic reticulum (ER) of producer cells. There, by unknown mechanisms, MANF plays a role in protein folding homeostasis in complex with the ER-localized Hsp70 chaperone BiP. Here we report that the SAF-A/B, Acinus, and PIAS (SAP) domain of MANF selectively associates with the nucleotide binding domain (NBD) of ADP-bound BiP. In crystal structures th ...[more]