Statistical dictionaries for hypothetical in silico model of the early-stage intermediate in protein folding.
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ABSTRACT: The polypeptide chain folding process appears to be a multi-stage phenomenon. The scientific community has recently devoted much attention to early stages of this process, with numerous attempts at simulating them--either experimentally or in silico. This paper presents a comparative analysis of the predicted and observed results of folding simulations. The proposed technique, based on statistical dictionaries, yields a global accuracy of 57%--a marked improvement over older approaches (with an accuracy of approximately 46%).
SUBMITTER: Kalinowska B
PROVIDER: S-EPMC4491364 | biostudies-literature |
REPOSITORIES: biostudies-literature
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