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Statistical dictionaries for hypothetical in silico model of the early-stage intermediate in protein folding.


ABSTRACT: The polypeptide chain folding process appears to be a multi-stage phenomenon. The scientific community has recently devoted much attention to early stages of this process, with numerous attempts at simulating them--either experimentally or in silico. This paper presents a comparative analysis of the predicted and observed results of folding simulations. The proposed technique, based on statistical dictionaries, yields a global accuracy of 57%--a marked improvement over older approaches (with an accuracy of approximately 46%).

SUBMITTER: Kalinowska B 

PROVIDER: S-EPMC4491364 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Statistical dictionaries for hypothetical in silico model of the early-stage intermediate in protein folding.

Kalinowska Barbara B   Fabian Piotr P   Stąpor Katarzyna K   Roterman Irena I  

Journal of computer-aided molecular design 20150326 7


The polypeptide chain folding process appears to be a multi-stage phenomenon. The scientific community has recently devoted much attention to early stages of this process, with numerous attempts at simulating them--either experimentally or in silico. This paper presents a comparative analysis of the predicted and observed results of folding simulations. The proposed technique, based on statistical dictionaries, yields a global accuracy of 57%--a marked improvement over older approaches (with an  ...[more]

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