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The Promise of Preventive Cancer Vaccines.

ABSTRACT: Years of unsuccessful attempts at fighting established tumors with vaccines have taught us all that they are only able to truly impact patient survival when used in a preventive setting, as would normally be the case for traditional vaccines against infectious diseases. While true primary cancer prevention is still but a long-term goal, secondary and tertiary prevention are already in the clinic and providing encouraging results. A combination of immunopreventive cancer strategies and recently approved checkpoint inhibitors is a further promise of forthcoming successful cancer disease control, but prevention will require a considerable reduction of currently reported toxicities. These considerations summed with the increased understanding of tumor antigens allow space for an optimistic view of the future.

SUBMITTER: Lollini PL

PROVIDER: S-EPMC4494347 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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The Promise of Preventive Cancer Vaccines.

Lollini Pier-Luigi PL Cavallo Federica F Nanni Patrizia P Quaglino Elena E

Vaccines 20150617 2

Years of unsuccessful attempts at fighting established tumors with vaccines have taught us all that they are only able to truly impact patient survival when used in a preventive setting, as would normally be the case for traditional vaccines against infectious diseases. While true primary cancer prevention is still but a long-term goal, secondary and tertiary prevention are already in the clinic and providing encouraging results. A combination of immunopreventive cancer strategies and recently a ...[more]

PMID: 26343198

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