Ontology highlight
ABSTRACT:
SUBMITTER: Chen Q
PROVIDER: S-EPMC4495399 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Chen Qian Q Zhang Nailing N Xie Rui R Wang Wei W Cai Jing J Choi Kyung-Suk KS David Karen Kate KK Huang Bo B Yabuta Norikazu N Nojima Hiroshi H Anders Robert A RA Pan Duojia D
Genes & development 20150601 12
The Hippo signaling pathway converges on YAP to regulate growth, differentiation, and regeneration. Previous studies with overexpressed proteins have shown that YAP is phosphorylated by its upstream kinase, Lats1/2, on multiple sites, including an evolutionarily conserved 14-3-3-binding site whose phosphorylation is believed to inhibit YAP by excluding it from the nucleus. Indeed, nuclear localization of YAP or decreased YAP phosphorylation at this site (S168 in Drosophila, S127 in humans, and S ...[more]