Force-induced remodelling of proteins and their complexes.
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ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC4499843 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Force-induced remodelling of proteins and their complexes.
Chen Yun Y Radford Sheena E SE Brockwell David J DJ
Current opinion in structural biology 20150221
Force can drive conformational changes in proteins, as well as modulate their stability and the affinity of their complexes, allowing a mechanical input to be converted into a biochemical output. These properties have been utilised by nature and force is now recognised to be widely used at the cellular level. The effects of force on the biophysical properties of biological systems can be large and varied. As these effects are only apparent in the presence of force, studies on the same proteins u ...[more]
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2020-08-01 | GSE127255 | GEO