Ontology highlight
ABSTRACT:
SUBMITTER: Baxa MC
PROVIDER: S-EPMC4500205 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Baxa Michael C MC Yu Wookyung W Adhikari Aashish N AN Ge Liang L Xia Zhen Z Zhou Ruhong R Freed Karl F KF Sosnick Tobin R TR
Proceedings of the National Academy of Sciences of the United States of America 20150622 27
Experimental and computational folding studies of Proteins L & G and NuG2 typically find that sequence differences determine which of the two hairpins is formed in the transition state ensemble (TSE). However, our recent work on Protein L finds that its TSE contains both hairpins, compelling a reassessment of the influence of sequence on the folding behavior of the other two homologs. We characterize the TSEs for Protein G and NuG2b, a triple mutant of NuG2, using ψ analysis, a method for identi ...[more]