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The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence.

ABSTRACT: Protein phosphatases Z that are unique to the fungal kingdom have been associated to resistance to high salt concentration, cell wall integrity, cell cycle regulation, and oxidative stress in fungi. In Aspergillus fumigatus, it was shown that PHZA is under the control of the transcription factor Skn7 and is only involved in the control of the oxidative stress. Accordingly, the ?phzA mutant showed a defect in virulence in an experimental model of corneal infection in immunocompetent animals and that the impact on susceptibility to cell wall drugs is only secondary.

SUBMITTER: Muszkieta L

PROVIDER: S-EPMC4503245 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence.

Muszkieta Laetitia L Carrion Steven de Jesus Sde J Robinet Pauline P Beau Rémi R Elbim Carole C Pearlman Eric E Latgé Jean-Paul JP

Fungal genetics and biology : FG & B 20140312

Protein phosphatases Z that are unique to the fungal kingdom have been associated to resistance to high salt concentration, cell wall integrity, cell cycle regulation, and oxidative stress in fungi. In Aspergillus fumigatus, it was shown that PHZA is under the control of the transcription factor Skn7 and is only involved in the control of the oxidative stress. Accordingly, the ΔphzA mutant showed a defect in virulence in an experimental model of corneal infection in immunocompetent animals and t ...[more]

PMID: 24614084

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Dataset Information

The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence.

Publications

The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence.

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