Ontology highlight
ABSTRACT:
SUBMITTER: Mohieldin AM
PROVIDER: S-EPMC4503369 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Mohieldin Ashraf M AM Haymour Hanan S HS Lo Shao T ST AbouAlaiwi Wissam A WA Atkinson Kimberly F KF Ward Christopher J CJ Gao Min M Wessely Oliver O Nauli Surya M SM
Cellular and molecular life sciences : CMLS 20150204 12
Dysfunction of many ciliary proteins has been linked to a list of diseases, from cystic kidney to obesity and from hypertension to mental retardation. We previously proposed that primary cilia are unique communication organelles that function as microsensory compartments that house mechanosensory molecules. Here we report that primary cilia exhibit membrane swellings or ciliary bulbs, which based on their unique ultrastructure and motility, could be mechanically regulated by fluid-shear stress. ...[more]