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Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE118050 | GEO | 2018/09/26

REPOSITORIES: GEO

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Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation.

Project description:Syndesmos (SDOS) is a functionally poorly characterized protein that directly interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS directly binds RNA in living cells. Combining individual gene expression profiling, nucleotide crosslinking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS. Among them, we identify a small subset of mRNAs responsible for the biogenesis of primary cilium that have been linked to developmental and degenerative diseases, known as ciliopathies, and cancer. We discover that SDOS binds and regulates the translation of several of these mRNAs, controlling cilia development.

| S-EPMC6294507 | biostudies-literature

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [iCLIP-seq]

Project description:We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS binds directly RNA in living cells. Combining individual gene expression profiling, nucleotide cross-linking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS.

2018-09-26 | GSE118049 | GEO

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Illumina array]

2018-09-26 | GSE118035 | GEO

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Ribo-seq]

Project description:We show here that NUDT16L1/TIRR/Syndesmos (SDOS) interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS binds directly RNA in living cells. Combining individual gene expression profiling, nucleotide cross-linking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS.

2018-09-26 | GSE117998 | GEO

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation

Project description:Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation

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A Novel Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-01-07 | E-GEOD-64691 | biostudies-arrayexpress

Kat2a regulates hippocampal memory formation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Ribo-seq]

Project description:Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Ribo-seq]

| PRJNA484185 | ENA

Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Illumina array]

Project description:Protein Syndesmos is a novel RNA binding protein that regulates primary cilia formation [Illumina array]

| PRJNA484186 | ENA

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