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Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation.

ABSTRACT: Syndesmos (SDOS) is a functionally poorly characterized protein that directly interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS directly binds RNA in living cells. Combining individual gene expression profiling, nucleotide crosslinking and immunoprecipitation (iCLIP), and ribosome profiling, we discover several crucial pathways regulated post-transcriptionally by SDOS. Among them, we identify a small subset of mRNAs responsible for the biogenesis of primary cilium that have been linked to developmental and degenerative diseases, known as ciliopathies, and cancer. We discover that SDOS binds and regulates the translation of several of these mRNAs, controlling cilia development.

SUBMITTER: Avolio R

PROVIDER: S-EPMC6294507 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation.

Avolio Rosario R Järvelin Aino I AI Mohammed Shabaz S Agliarulo Ilenia I Condelli Valentina V Zoppoli Pietro P Calice Giovanni G Sarnataro Daniela D Bechara Elias E Tartaglia Gian G GG Landriscina Matteo M Castello Alfredo A Esposito Franca F Matassa Danilo S DS

Nucleic acids research 20181201 22

Syndesmos (SDOS) is a functionally poorly characterized protein that directly interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively translating polyribosomes and represses translation. Moreover, we demonstrate that SDOS directly binds RNA in living cells. Combining individual gene expression profiling, nucleotide crosslinking and immunopr ...[more]

PMID: 30260431

Dataset Information

Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation.

Publications

Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation.

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