Ontology highlight
ABSTRACT:
SUBMITTER: Kim W
PROVIDER: S-EPMC4505604 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Kim Wonho W Kim Hag Dong HD Jung Youjin Y Kim Joon J Chung Jongkyeong J
The Journal of biological chemistry 20150409 21
During animal development, various signaling pathways converge to regulate cell growth. In this study, we identified LTV1 as a novel cell growth regulator in Drosophila. LTV1 mutant larvae exhibited developmental delays and lethality at the second larval stage. Using biochemical studies, we discovered that LTV1 interacted with ribosomal protein S3 and co-purified with free 40S ribosome subunits. We further demonstrated that LTV1 is crucial for ribosome biogenesis through 40S ribosome subunit syn ...[more]