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Invasive infection due to Saprochaete capitata in a young patient with hematological malignancies.

ABSTRACT: We report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole.

SUBMITTER: Parahym AM

PROVIDER: S-EPMC4507546 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Invasive infection due to Saprochaete capitata in a young patient with hematological malignancies.

Parahym Ana Maria Rabelo de Carvalho AM Rolim Neto Pedro José PJ da Silva Carolina Maria CM Domingos Igor de Farias Ide F Gonçalves Sarah Santos SS Leite Edinalva Pereira EP de Morais Vera Lúcia Lins VL Macêdo Danielle Patrícia Cerqueira DP de Lima Neto Reginaldo Gonçalves RG Neves Rejane Pereira RP

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] 20150601 2

We report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole. ...[more]

PMID: 26273269

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Project description:Adult patients with hematological malignancies are frequently accompanied by bacterial infections in the lungs when they are first diagnosed. Sputum culture, procalcitonin (PCT), C-reactive protein (CRP), body temperature, and other routinely used assays are not always reliable. Cytokines are frequently abnormally produced in adult hematological malignancies associated with a lung infection, it is uncertain if cytokines can predict lung bacterial infections in individuals with hematological malignancies. Therefore, we reviewed 541 adult patients newly diagnosed with hematological malignancies, of which 254 patients had lung bacterial infections and 287 patients had no other clearly diagnosed infections. To explore the predictive value of cytokines for pulmonary bacterial infection in adult patients with hematological malignancies. Our results show that IL-4, IL-6, IL-8, IL-10, IL-12P70, IL-1β, IL-2, IFN-γ, TNF-α, TNF-β and IL-17A are in the lungs The expression level of bacterially infected individuals was higher than that of patients without any infections (P<0.05). Furthermore, we found that 88.89% (200/225) of patients with IL-6 ≥34.12 pg/ml had a bacterial infection in their lungs. With the level of IL-8 ≥16.35 pg/ml, 71.67% (210/293) of patients were infected. While 66.10% (193/292) of patients had lung bacterial infections with the level of IL-10 ≥5.62 pg/ml. When IL-6, IL-8, and IL-10 were both greater than or equal to their Cutoff-value, 98.52% (133/135) of patients had lung bacterial infection. Significantly better than PCT ≥0.11 ng/ml [63.83% (150/235)], body temperature ≥38.5°C [71.24% (62/87)], CRP ≥9.3 mg/L [53.59% (112/209)] the proportion of lung infection. In general. IL-6, IL-8 and IL-10 are abnormally elevated in patients with lung bacterial infections in adult hematological malignancies. Then, the abnormal increase of IL-6, IL-8 and IL-10 should pay close attention to the possible lung bacterial infection in patients.

Dataset Information

Invasive infection due to Saprochaete capitata in a young patient with hematological malignancies.

Publications

Invasive infection due to Saprochaete capitata in a young patient with hematological malignancies.

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