Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC4510653 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Zhou Yue Y Yamada Naoki N Tanaka Tomohiro T Hori Takashi T Yokoyama Satoru S Hayakawa Yoshihiro Y Yano Seiji S Fukuoka Junya J Koizumi Keiichi K Saiki Ikuo I Sakurai Hiroaki H
Nature communications 20150709
Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been reported that ligand-independent phosphorylation of EphA2 at Ser-897 is induced by Akt. We show that inflammatory cytokines promote RSK-, not Akt-, dependent phosphorylation of EphA2 at Ser-897. In addition, the RSK-EphA2 signal ...[more]