Ontology highlight
ABSTRACT:
SUBMITTER: Drewes JL
PROVIDER: S-EPMC4512924 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Drewes Julia L JL Meulendyke Kelly A KA Liao Zhaohao Z Witwer Kenneth W KW Gama Lucio L Ubaida-Mohien Ceereena C Li Ming M Notarangelo Francesca M FM Tarwater Patrick M PM Schwarcz Robert R Graham David R DR Zink M Christine MC
Journal of neurovirology 20150317 4
Activation of the kynurenine pathway (KP) of tryptophan catabolism likely contributes to HIV-associated neurological disorders. However, KP activation in brain tissue during HIV infection has been understudied, and the effect of combination antiretroviral therapy (cART) on KP induction in the brain is unknown. To examine these questions, tryptophan, kynurenine, 3-hydroxykynurenine, quinolinic acid, and serotonin levels were measured longitudinally during SIV infection in the striatum and CSF fro ...[more]